. BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathol. 2018 May;135(5):695-710. Epub 2018 Jan 11 PubMed.


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  1. The work by Peters et. al is beautiful and comprehensive in quantitation of plaque growth and formation. They clearly demonstrated better efficacy of the β-secretase inhibitor before individual plaque formation, suggesting that treating during a period of new plaque formation, or even before, will be most effective. This would translate to the 10–20 years before symptom onset in DIAN.

    A caveat of the work is that the mouse model overexpresses Aβ production, so the concentrations and kinetics may not replicate typical human plaque growth.

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  1. BACE Block Nips New Plaques in the Bud, Old Ones Keep Growing