. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci. 2005 Mar 2;25(9):2386-95. PubMed.


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  1. Having read this paper, Larry Goldstein's paper, his group's reply, and comments carefully, it is difficult to explain their drastically different results. Short of having done the experiments oneself, there is no obvious reasoning as to how to reconcile the differences. All the same, these papers address an important topic concerning AD pathogenesis. Rather than focus on experimental details, we should design experiments to either strengthen the axonal transport hypothesis or provide sufficient data to support a competing hypothesis. This way, the field can be moved forward.


    . Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25;307(5713):1282-8. PubMed.

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