. Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity. Eur J Neurosci. 2007 Feb;25(4):1079-86. PubMed.


Please login to recommend the paper.


  1. The interesting paper of Rusu and coworkers describes that axonal accumulation of synaptic markers in the fruit fly depends on the NPTY motif of APP. APP overexpression induced a partial but characteristic axonal transport phenotype, which correlated with deficits in short-term synaptic plasticity. This report further supports previous findings in mouse models with mutant or wild-type APP overexpression (1,2), which also elicit aberrant intraneuronal accumulation of Aβ peptides upon reduction of kinesin-I (1). This is an interesting link as intraneuronal Aβ accumulation correlates well with age-dependent axonal degeneration (3,4) and neuron loss of CA1 pyramidal cells (5,6) in two different APP/PS1 mouse lines. It would be interesting to learn whether the NPTY-dependent axonal phenotype in the fruit fly is also based on elevated (intracellular) Aβ accumulation.


    . Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005 Feb 25;307(5713):1282-8. PubMed.

    . Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 6;51(1):29-42. PubMed.

    . Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol. 2006 Apr;111(4):312-9. PubMed.

    . Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging. 2007 Nov;28(11):1689-99. PubMed.

    . Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2004 Apr;164(4):1495-502. PubMed.

    . Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol. 2004 Oct;165(4):1289-300. PubMed.

Make a Comment

To make a comment you must login or register.

This paper appears in the following:


  1. San Diego: Exploring the Role of APP in Transit