. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. JAMA Neurol. 2018 Dec 3; PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ42
(CSF)
AD
(397)
136 ± 47
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
McKhann et al., 2011; McKhann et al., 1984
Aβ42
(CSF)
PD
(41)
262 ± 63
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
Hughes et al., 1992
NFL
(CSF)
AD
(397)
1212 ± 1147
pg/mL §
ELISA;
Other/Not Specified;
In-house
McKhann et al., 2011; McKhann et al., 1984
NFL
(CSF)
ALS
(68)
5391 ± 4138
pg/mL §
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
CBS
(21)
1988 ± 1470
pg/mL §
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
CTRL-
CNC
(75)
763 ± 1047
pg/mL §
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
DLB
(33)
1936 ± 3703
pg/mL §
ELISA;
Other/Not Specified;
In-house
McKeith et al., 2005
NFL
(CSF)
FTD-
bvFTD
(46)
2082 ± 1657
pg/mL §
ELISA;
Other/Not Specified;
In-house
Rascovsky et al., 2011
NFL
(CSF)
FTD-
nfvPPA
(20)
1637 ± 908
pg/mL §
ELISA;
Other/Not Specified;
In-house
Gorno-Tempini et al., 2011
NFL
(CSF)
FTD-
svPPA
(18)
2276 ± 1418
pg/mL §
ELISA;
Other/Not Specified;
In-house
Gorno-Tempini et al., 2011
NFL
(CSF)
PD
(41)
1069 ± 1881
pg/mL §
ELISA;
Other/Not Specified;
In-house
Hughes et al., 1992
NFL
(CSF)
PDD
(29)
1294 ± 955
pg/mL §
ELISA;
Other/Not Specified;
In-house
NFL
(CSF)
PSP
(20)
2303 ± 1473
pg/mL §
ELISA;
Other/Not Specified;
In-house
neurogranin
(CSF)
AD
(397)
253 ± 187
pg/mL §
ELISA;
Other/Not Specified;
In-house
McKhann et al., 2011; McKhann et al., 1984
neurogranin
(CSF)
PD
(41)
140 ± 114
pg/mL §
ELISA;
Other/Not Specified;
In-house
Hughes et al., 1992
tau-p181
(CSF)
AD
(397)
43 ± 28
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
McKhann et al., 2011; McKhann et al., 1984
tau-p181
(CSF)
PD
(41)
20 ± 8
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
Hughes et al., 1992
tau-total
(CSF)
AD
(397)
123 ± 76
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
McKhann et al., 2011; McKhann et al., 1984
tau-total
(CSF)
PD
(41)
44 ± 19
pg/mL §
xMAP;
INNOBIA AlzBio3;
Fujirebio
Hughes et al., 1992

§ Data supplied to Alzforum by author

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