Houlden H, Rizzu P, Stevens M, de Knijff P, van Duijn CM, van Swieten JC, Heutink P, Perez-Tur J, Thomas V, Baker M, Morris H, Rossor M, Jannsen JC, Petersen RC, Dodd P, Dark F, Boeve B, Dickson D, Davies P, Pickering-Brown S, Mann D, Adamson J, Lynch T, Payami H, Hardy J. Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations. Neurosci Lett. 1999 Feb 5;260(3):193-5. PubMed.
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Osaka City University Medical School
The paper tells something about the molecular mechanism for ApoE function by evidence that ApoE influences development of dementia rather than onset time.
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