. Antibody response and plasma Abeta1-40 levels in young Microcebus murinus primates immunized with Abeta1-42 and its derivatives. Vaccine. 2009 Feb 11;27(7):957-64. PubMed.

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Comments

  1. The strong point for the Microcebus model is the early development of Aβ42 aggregates, as in humans (Mestre et al., 2000). I am not sure that the induced increase of specific antibodies against Aβ40 is a good sign.

    References:

    . Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles. Neurobiol Dis. 2000 Feb;7(1):1-8. PubMed.

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