Ding TT, Lee SJ, Rochet JC, Lansbury PT.
Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.
Biochemistry. 2002 Aug 13;41(32):10209-17.
PubMed.
Much work has been done on the structure of aggregated alpha-synuclein, but this is one of the first papers to examine the structure of protofibrillar alpha-synuclein associated with membranes. This is important because prior studies suggest that membrane-bound synuclein aggregates more readily than free synuclein.
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Boston University School of Medicine
Much work has been done on the structure of aggregated alpha-synuclein, but this is one of the first papers to examine the structure of protofibrillar alpha-synuclein associated with membranes. This is important because prior studies suggest that membrane-bound synuclein aggregates more readily than free synuclein.
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