. The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression. J Biol Chem. 2008 Aug 22;283(34):22992-3003. PubMed.


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  1. A very important and interesting piece of work. The "γ-secretase inhibitor paradox" may have been given a solution. The evidence would be more compelling if the authors could show similar phenomena in other (similar) proteolytic processes.

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