. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13554-9. PubMed.


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  1. BACE is thought to be a potentially important target for therapeutic intervention in AD. BACE1 knockouts appear to be healthy, which suggests that inhibiting BACE might be therapeutically viable. An essential step in predicting any potential toxicity that might be associated with BACE inhibition is identifying its substrates. This paper is important because it has identified the first substrate for BACE other than APP.

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