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  1. This paper provides an additional aspect to the story of altered neuroplasticity in the AD brain. Although dendritic (e.g., Buell and Coleman, 1979) and GAP-43 data (Coleman et al., 1992) indicate reduced plasticity in AD brain, localized increased neuritic proliferation around plaques has been demonstrated (e.g., Masliah et al., 1991). The present paper suggests that the localized sprouting around plaques may be related to the association of NgR and APP, although the association is complicated by the effect of NgR on Aβ production.


    . Dendritic growth in the aged human brain and failure of growth in senile dementia. Science. 1979 Nov 16;206(4420):854-6. PubMed.

    . Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease. Neurobiol Aging. 1992 Nov-Dec;13(6):631-9. PubMed.

    . Patterns of aberrant sprouting in Alzheimer's disease. Neuron. 1991 May;6(5):729-39. PubMed.

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