. Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11686-91. PubMed.


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  1. As a practitioner with years of experience caring for clients with AD, I can say that sundowning is definitely a biological phenomenon. This is an important area of research, at least in terms of symptom management.

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