. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease. J Neurochem. 1997 Dec;69(6):2494-9. PubMed.


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  1. This is the first document to the effect of PS-1 mutation on alpha-secretase.

  2. It is important to understand amyloid production as it relates to presenilin function and apolipoprotein E. The current hypothesis to emphasize Abeta1-42(43) is not enough and should be examined more using in vivo materials such as brain tissues.

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