. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci. 2009 Aug 26;29(34):10741-9. PubMed.


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  1. Terrific paper. It helps explain what is happening with tau pathology earlier in the process.

    If the early tau pathology is reversible, with neurons still living but impaired, one wonders, What are our treatment options? I am particular curious, of course, about possible nutritional approaches.

    Emerson Lombardo, NB, Volicer L, Martin A, Wu B. Zhang XW. (2006) Memory preservation diet™ ©2005 to Reduce Risk and Slow Progression of Alzheimer's Disease (AD). In Vellas B, Grundman M, Feldman H, Fitten LJ, Winblad B, editors, Research and Practice in Alzheimer's Disease and Cognitive Decline, vol 9: 138-59.

    Emerson Lombardo NB. Martin A. Volicer L. Mandell A. Wen Zhang X. (2006) Comprehensive whole foods diet to reduce risk and slow progression of Alzheimer’s disease. J Nutri Health & Aging 10(3) 211.

    Otsuka M, Sato T, Ueki A. (2004) The effect of nutritional intervention on cognitive function in patients with AD J Nutri Health & Aging 8 (5): 428.

  2. This is a very carefully performed behavioral and electrophysiological study of an established tau mouse model. AD is a synapse failure.

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  1. Tau Sullies Synaptic Function

Research Models

  1. htau