Medina DX, Orr ME, Oddo S. Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice. Neurobiol Aging. 2014 Jan;35(1):79-87. PubMed.

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Research Models

  1. TARDBP (A315T) (congenic)

Mutations