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Washington University
This is an interesting paper showing that contextual fear learning deficits are present in Tg2576 mice and in PS1XTg2576 mice as early as 5 months of age. The authors hypothesize this may be a useful test to quickly screen effects of altering Abeta. This may be true. The data are convincing. It is interesting to note, however, that by the time a human develops even the earliest cognitive changes indicative of AD (ie. Decreases in recent memory), there is already a huge plaque load in the brain. In contrast, some behavioral tests are abnormal in APP transgenic mice, such as this test, at an age prior to plaques. How this behavioral abnormality in mice relates to the earliest symptoms in AD seen in humans is not clear. Some behavioral abnormalities in APP transgenic mice seem to worsen or correlate with plaques, others don't. The abnormalities in memory shown in this paper prior to plaques could be due to some form of Abeta but it is conceivable they are due to APP overexpression or some other factor.
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