. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998 Jan;4(1):97-100. PubMed.


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  1. Undoubtedly this paper indicates an AD model to show neuropathological change and enables us to analyze the detailed study. It is important to be aware that the behavioral change appears before neuropathological changes such as the plaque formation.

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Research Models

  1. PS/APP
  2. PS1(M146L)


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Research Timeline Event

  1. First double-transgenics expressing mutant APP and PSEN1