To Sleep, Perchance to Clean…the Brain, Make Memories

Researchers have tied sleep to clearance of waste products such as excess Aβ. New research suggests this clearance may be driven by a change in the extracellular ion composition, which swells the interstitial fluid. Other work finds an essential role for a signaling pathway involving the kinase complex mTORC1 and the electrical rhythms of REM sleep. Read Madolyn Rogers' two-part series.