Series

To Sleep, Perchance to Clean…the Brain, Make Memories

Researchers have tied sleep to clearance of waste products such as excess Aβ. New research suggests this clearance may be driven by a change in the extracellular ion composition, which swells the interstitial fluid. Other work finds an essential role for a signaling pathway involving the kinase complex mTORC1 and the electrical rhythms of REM sleep. Read Madolyn Rogers' two-part series.