Physicians often hear from their older patients, “My memory just isn’t what it used to be.” For some, this perception of mental slippage, too slight to be detected on any cognitive test, may signal early Alzheimer’s disease. Such subjective cognitive decline (SCD) remains tricky to define and measure, and the basis for it has been equally elusive. Is there a pathological process already underway in the brain, or some other less dire explanation?
- Subjective cognitive decline can be an early sign of AD, but its neurological basis is unknown.
- In PET scans of healthy old people, SCD correlated with tau in the entorhinal cortex, less so with amyloid.
- SCD may flag tau accumulation.
Two new studies look at why and when subjective changes appear, and how best to measure them. Using tau-PET imaging in healthy older adults, Rebecca Amariglio and colleagues at Massachusetts General Hospital in Charlestown found that SCD correlated most strongly with the presence of neurofibrillary tangles in the entorhinal cortex, and to a lesser extent with amyloid load. The results, published on October 2 in JAMA Neurology, indicate that subjective memory complaints could be the first outward sign of tau build-up in the brain. Whether that tau deposition is a normal part of aging, or the beginnings of AD, remains to be determined.
Not everyone with SCD goes on to develop AD. The challenge is to figure out who will and who won’t. In a second study, Yakeel Quiroz at MGH in Boston went looking for clues in the Colombian early onset AD kindred, in which carriers of the PSEN1 Paisa mutation develop an aggressive form of early onset AD accompanied by subtle brain changes that start in childhood (Jul 2015 news). In a new study, Quiroz found that mutation carriers reported higher levels of subjective memory complaints (SMCs) than noncarriers in the decades before onset of symptoms, but SMCs did not increase with age. Thus, in this young cohort destined to develop AD, memory complaints do not escalate as disease progresses. That work appeared September 6 in Neurology.
Previous work from Amariglio’s group and others used PET to relate concerns about memory to amyloid deposition in the brain. They found the more amyloid, the more concerns (Amariglio et al., 2012; Perrotin et al., 2012). In the new study, first author Rachel Buckley expanded the work, scanning 133 healthy adults from the Harvard Aging Brain Study with the tau ligand flortaucipir, a.k.a. AV1451. The average age of participants was 76, and they were free of signs of dementia or depression. Buckley quizzed them about memory and other cognitive complaints, generating a composite score for SCD. The same people also underwent PET scanning with PiB to detect amyloid.
For tau-PET, Buckley focused on two brain regions—the entorhinal and inferior temporal cortices. The former begins to accumulate tau during normal aging, which then spreads to the temporal cortex as amyloid load accrues.
The researchers found that SCD scores correlated most strongly with entorhinal tau, to a lesser extent with amyloid levels, and not at all with tau in the inferior temporal cortex. In a model that combined amyloid and tau, the latter dominated, while the amyloid contribution disappeared. “The tau effect really swamped any role for amyloid,” said Amariglio. The two did not interact, but both were independently associated with SCD. In a testament to how tricky it is to understand subjective complaint, low mood also correlated with higher SCD scores, as expected from previous work.
“This new work confirms what we’ve found in our autopsy studies,” noted Richard Kryscio, University of Kentucky, Lexington. “We have associated SCD with an excess of tangles in the medial temporal lobe, which includes the entorhinal cortex,” he told Alzforum (Kryscio et al., 2016).
The researchers don’t know if tau deposition and associated SCD is a consequence of aging, or early AD, but they are performing serial measurements of tau and cognition to track progression in their cohort. “We want to see who progresses to AD pathology and who doesn’t, and that might help determine which part of this tau story reflects simply aging and which doesn’t,” said Amariglio.
In the Colombian study, first author Daniel Norton assessed 26 mutation carriers and 26 noncarriers between the ages of 24 and 53 for SMCs, a measure comparable but not identical to Buckley’s SCD. None of the participants know their genetic status.
Overall, the carriers as a group showed higher SMC scores than noncarriers, suggesting that SMC does reflect early cognitive changes related to AD. However, when the investigators plotted scores as a function of age, the number of self-reported SMCs stayed steady with time in both carriers and noncarriers. In contrast, reports from close family members or caregivers of carriers increased over time, and peaked near the time of first symptoms.
Due to the small sample size, Quiroz said they cannot be sure why self-report did not increase with age, even in the face of ongoing disease progression. One possibility is that carriers’ abilities to assess their own memory difficulties diminish with time and encroaching dementia, but that remains to be proven, she said.
The data emphasize the value of partner reports over solely self-report, which has been a matter of debate in the field, said Quiroz. “In this case the study partner report is very powerful,” she told Alzforum.
While it is unclear how familial AD compares to more common late-onset, John Ringman, Keck School of Medicine, Los Angeles, said the data fit with his clinical experience. “Caregiver or family member reports are more robust in predicting the presence of AD or neurodegenerative disease,” he told Alzforum. Ringman said he also puts more weight on parameters that measure change over time, which the current study did not assess. Finally, he stressed the role for anxiety. “The study controlled for depression, but ideally they would also control for anxiety, because people are expressing worry about their mental capacities,” he said.
The underlying cause of SCD in familial AD remains to be clarified. Compared with late-onset AD, the Colombian subjects were much younger and less likely to have age-related tau deposition. In the DIAN study of autosomal-dominant AD, subjects remained mainly negative for tau by PET scans until disease onset, after which tau increased quickly (Aug 2017 conference news). In the Colombian families, Quiroz said she saw increased tau levels in some carriers six years from clinical onset, raising the possibility that tau may factor into SMC in this cohort (Feb 2016 conference news).
Together, the two studies highlight a challenge facing researchers who study subjective changes, said Christoph Laske, University Hospital of Tübingen in Germany. “That both papers are using different terms (SCD versus SMC) and different quantitative measures for subjective memory problems demonstrates the urgent need to better standardize this research topic in the near future," Laske wrote in an email to Alzforum.—Pat McCaffrey
- Familial Alzheimer’s Gene Alters Children’s Brains
- Data from DIAN Revise Familiar Biomarker Trajectories
- Tau Tracers Track First Emergence of Tangles in Familial Alzheimer’s
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