The N- and C-terminals of synthetic Aβ1-42 were differentially labeled with 3H and 14C and then used as a probe to measure degradation by injection into rat hippocampus. Effects of various protease inhibitors and two dimensional HPLC analysis of degradation products lead Saido (122.12) to conclude that neprilysin (NEP) or an NEP-like protease is responsible for the degradation of A-beta in vivo.—Dominic Walsh


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