Confused about protein liquid-liquid phase transitions? You are not alone. Researchers working in this emerging field gathered in Leuven in early May to make sense of the latest data linking protein droplets to biological function and disease. Read Tom Fagan’s report, and come away with a clearer sense of membraneless organelles, and their disassembly and transport back into the nucleus, where they belong. Be ready for wild ideas about low-complexity domains as internal chaperones and plant drought protection mechanisms, echoing what’s going on with these neurodegenerative disease proteins.
At a topical meeting in Leuven, Belgium, a coherent picture began to emerge for how these membraneless organelles function in health and disease.