Fiendishly complicated, γ-secretase has proved a formidable foe to the structurally minded scientist. But goaded by éminence grise T.I., this Japanese bunch of rebels is deploying the force of SCAM and other stratagems to conquer it yet. Following our initial Keystone Treatment News series, read our next series of stories from the March 2008 Alzheimer Disease conference in Keystone, Colorado. Learn how some rebels explore the bends and recesses of the enzyme’s deep space, while others take on elusive science mysteries of Alzheimerology. May the Force be with them.