CONFERENCE COVERAGE SERIES
International Conference on Alzheimer's Disease 2002
20 – 25 July 2002
Stockholm: Visualizing Amyloid Biggest Draw at Imaging Symposium, Consensus Sought on Validation
Stockholm. Read our coverage of the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, starting with this report of advances in imaging methods and a promising new live amyloid marker.
Stockholm: Chlamydia Triggers Amyloid Plaques in Mice
Brian Balin and colleagues at the Philadelphia College of Osteopathic Medicine presented data showing that chlamydia isolated from Alzheimer’s brain, cultured, and then sprayed into the noses of young wild-type BALB/c mice can cause progressive deposition of amyloid plaques...
Stockholm: Aph-1 and Pen-2: New Names in the Presenilin Debate Complete the Complex?
Are two new proteins the missing links to understand the γ-secretase complex? Research presented today at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm suggests as much. Are more components yet to be discovered?
Stockholm: Clusterin (or Beware the Evil Chaperone!)
Today at the 8th International Conference on Alzheimer’s Disease and Related Disorders, David Holtzman's group reports that the lipid-binding protein ApoJ modulates the formation of amyloid deposits and neuritic toxicity in vivo.
Stockholm: Gold in Them Thar Hills?
Coverage by Keith Crutcher from the Genetics Symposium at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Stockholm: Not All NSAIDs Are Equally Good When it Comes to Alzheimer’s
Course Correction on NSAIDs: Reanalysis of Rotterdam data suggest only those NSAIDs that appear to affect AβPP processing protect against AD.
Stockholm: Separating Good from Bad Inflammation in AD: Complement Steps into Limelight
Tony Wyss-Coray and colleagues are reporting that disabling the complement cascade, known for its role in innate immunity, causes hippocampal neurodegeneration and exacerbates amyloid deposition. Could this be a way in which microglial activation is beneficial in AD?
Stockholm: Larger Study Finds Protective Effect of Statin Use
More epidemiological data is being reported at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm to strengthen the association between statin use and lower risk for AD.
Stockholm: Liver Found to Degrade Aβ
The Aβ peptide that circulates in the periphery is degraded not primarily by the kidney, but in the liver, scientists report at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm.
Stockholm: Bad News Official: The Rofecoxib and Naproxen Clinical Trial Has Failed
The latest clinical trial of two non-steriodal anti-inflammatory drugs has shown no efficacy.
Stockholm: Presenting α-T Catenin: A Long-Awaited Gene on Chromosome 10?
Is α-T catenin the elusive LOAD gene on chromosome 10? Or is it one of several genes? Read about Steve Younkin et al.'s presentation at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm...
Stockholm: Educated Guessing Game: Which Genes Does “Other” APP Snippet Regulate?
Researchers in several labs are trying to discover the genes whose expression might be controlled by the C-terminal fragment of APP. The answer is not yet in, but read about some clues presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders...
Stockholm: Could a Whiff of NAP Nip Brain Inflammation in the Bud?
Researchers from Israel presented information about a highly potent peptide that, in rodents, shows promise as a future neuroprotective treatment.
Stockholm: There Is No Spatial Paradox!
More news updates from the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm: In a wide-ranging and eloquent presentation, Christian Haass provided several experimental proofs that a small amount of presenilin is detected at the plasma membrane...
Stockholm: The Presenilin Signaling Hub—A RIP-off or the Real Deal?
Ever since Cao and Sudhof provided the first evidence that the intracellular domain of APP (AICD) translocates to the nucleus and may be involved in transcriptional regulation, there has been a reawakening of interest in APP function...
Stockholm: Degradation on the Rise
Malcolm Leissring reports on the latest data, presented at the 8th International Conference on Alzheimer’s Disease and Related Disorders in Stockholm, on the role of insulin-degrading enzyme and neprilysin in degrading Aβ peptide in vivo....
Stockholm: Core Resistance
Keith Crucher reports from the World Alzheimer Congress: In the symposium on amyloid-lowering strategies, Dennis Dickson presented a unique and clever approach to addressing the likelihood that macrophage-mediated clearance of amyloid will be an effective strategy in humans....
Stockholm: Pictures at an Exhibition
Keith Crutcher reports on the World Alzheimer Congress in Stockholm. "From the relatively crude days of CT scans to the truly impressive detail now being offered by functional MRI, this revolution in imaging technology is making it possible to study the course of AD in ways previously unimaginable...."