CONFERENCE COVERAGE SERIES
Human Amyloid Imaging 2016
13 – 15 January 2016
Off-target troubles aside, tau tracers took the cake at the 10th Human Amyloid Imaging conference, held January 13-15 in Miami Beach, Florida. Even as researchers continue to sort out the vagaries of working with investigational tracers, they have started delving into deeper questions than whether neurofibrillary tangles are merely present in the brain. Scientists are asking how patterns of tau deposition relate to Aβ, neurodegeneration, and connectivity in Alzheimer’s disease. Preliminary cross-sectional data hint at a considerable lag between Aβ and tau accumulation in familial AD. New ligands debuted at HAI this year, but whether they will better detect tau deposits than the current batch remains to be seen. Leaders in the field still don’t know how well tau PET will work in other forms of dementia, such as FTD, PSP, and CBD.
Tau Takes Center Stage at 10th Human Amyloid Imaging Conference
Using PET, researchers are trying to match tau spread against structural and functional defects.
Tau Tracers Track First Emergence of Tangles in Familial Alzheimer’s
Preliminary data suggests a long lag between Aβ and tau deposits as the disease develops.
Shaky Specificity of Tau PET Ligands Stokes Debate at HAI
Attendees grapple with conflicting binding results
At HAI, Researchers Explore Diagnostic Potential of a Tau Tracer
AV1451 appears too weak to diagnose non-AD tauopathies.