Holtzman et al. (Abstract 612) reported that 95 percent of immunoreactive β-amyloid in human cerebral spinal fluid is bound to the ER chaperone Erp57. Anti-Erp57 and anti-Aβ antibodies were found to react with an approximately 62 kDα band even after SDS-PAGE suggesting that these two proteins form a tight complex. Immunoreactivity of protein extracts from Alzheimer's disease (AD) CSF was not studied.—June Kinoshita


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