CONFERENCE COVERAGE SERIES

5th RNA Metabolism in Neurological Disease Conference

San Diego, California

01 – 02 November 2018

When RNA transcripts aren’t processed properly or don’t make it to their final destinations for translation into protein, the consequences could trigger neurodegenerative disease. At the 5th RNA Metabolism in Neurological Disease meeting, researchers reported how RNA-binding proteins tasked with keeping transcripts in order manage to fall out of line themselves—gelling with other proteins and RNA in cytoplasm. Scientists linked previously disparate mechanisms of C9ORF72 toxicity into cohesive feed-forward loops, and hatched plans for new therapeutic approaches.