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Benedict Albensi, PhD

University of Manitoba

Contact Information

Benedict Albensi, PhD
BAlbensi [at] sbrc [dot] ca
Phone: 204/235-3942
Winnipeg, Canada

Professional Information

Associate Professor, Manitoba Dementia Research Chair, and Everett Endowment Fund Chair
University of Manitoba


PhD. in Neuroscience, University of Utah. Postdoctoral Fellow, Georgetown Inst. of Cognitive & Computational Sci., Georgetown Univ. with Dr. James Pekar and Dean, Dr. Alan Faden. Postdoctoral Scholar, Univ. of Kentucky, with Dr. Mark Mattson.


My laboratory is focused on understanding the biological basis of memory. In addition, we study NF-kB signaling pathways that play a roll not only in normal memory, but also in Alzheimer's disease. Current and/or Past manuscripts/studies include:

* The role of creatine and mitochondrial dysfunction in memory impairment in AD
* NF-kB p50 subunit knock out leads to impairments in LTP and memory (MWM)
* The role of presenilin mutations in synaptic plasticity and Alzheimer's disease
* Hypoxia-ischemia in the neonatal vs. adult hippocampus
* Temporal evolution of traumatic brain injury (TBI) in the adult hippocampus
* Distribution of N-type calcium channels in human and rat hippocampus
* Mitochondrial membrane permeability transition, TBI, and hippocampal synaptic plasticity
* Tumor necrosis factor and hippocampal synaptic plasticity
* Spider toxins, NMDA/AMPA-receptor mediated transmission, and hippocampal synaptic plasticity
* Suppression of epileptiform activity by prolonged electrical stimulation in the hippocampus

Prior investigations have also attempted to identify therapeutic targets (glutamate receptors, oxidative stress intermediates, cytokines, and ionic channels) in CNS diseases and pathology such as in dementia, stroke, head trauma, and processes of aging, etc. This has included work with natural products for drug discovery.

I am also on the Board of Directors for the Alzheimer's Society of Manitoba