Posted 07 Mar 2019
The National Institutes of Health
To apply: Please send a cover letter, curriculum vitae, bibliography, statement of research interests, and three letters of recommendation to: Angela Prazak, Staff Assistant; Office of the Scientific Director; Vacancy # NIA-IRP-19-08; National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 04C230, Baltimore, MD 21224, or email: email@example.com. Applications must reference the Vacancy # and be received on or before April 9, 2019, for consideration.
The National Institute on Aging (NIA), Intramural Research Program (IRP), a major research component of the National Institutes of Health (NIH) in the Department of Health and Human Services (DHHS), is recruiting for a staff scientist in the Clinical and Translational Neuroscience Unit (CTNU) of the Laboratory of Behavioral Neuroscience (LBN) in Baltimore, MD. The overall goals of the CTNU are to study the metabolic basis of Alzheimer’s disease pathogenesis in humans, identify changes in central and systemic metabolism in preclinical stages of disease progression, and pinpoint the principal regulators of key metabolic pathways that may present plausible targets for disease modification. To achieve these goals, the CTNU applies mass spectrometry-based proteomics and metabolomics for the discovery of novel biomarkers associated with both disease pathology assessed in postmortem brain tissue as well as endophenotypes of disease including changes in brain structure, function and pathology. These methods rely on large clinical and neuroimaging datasets as well as brain and blood tissue samples available within the Baltimore Longitudinal Study of Aging (BLSA) as well as other datasets including the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Predictors of Cognitive Decline Among Normal Individuals (BIOCARD) Study, and the Religious Orders Study (ROS). Excellent written and oral (English) communication skills are required. The incumbent will have a major role in assisting the Unit Chief in project management, manuscript preparation and experimental design, training postdoctoral fellows and postbaccalaureate students, managing both internal and external lab meetings, and maintaining research continuity within the laboratory.
This staff scientist will have extensive experience in using epidemiologic and biostatistical methods to model associations between ‘OMICS’-derived predictors and longitudinal outcomes associated with AD within well characterized datasets such as those described above. Experience in managing and curating large ‘OMICS’ datasets for both internal as well as external international collaborations, including the use of closed- and open-source platforms to manage and review code and data is required. Additionally, the individual will have both laboratory and administrative experience in coordinating with tissue repositories, pre-processing and international shipping of human tissue, receiving data from mass spectrometry platforms, and developing analytic pipelines to generate usable ‘OMICS’ data. A background in research with neurodegenerative diseases, including AD is required.
Staff Scientists do not receive independent resources, although they often work independently and have sophisticated skills and knowledge essential to the work of the Laboratory. Although this staff scientist will be supervised by the Unit Chief, he/she will be interacting with the scientists from the IRP and scientific community at large. The successful candidate will have experience in collaborative research documented in publications and more generally will have a history of publications that reflect experience in the analytical requirements of this position.
DHHS and NIH are Equal Opportunity Employers.
The NIH is dedicated to building a diverse community in its training and employment programs.
The successful individual must have a Ph.D., or M.D., or equivalent doctoral degree in biomedical sciences or related fields. Salary is commensurate with research experience and accomplishments. A full Civil Service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available. All employees of the federal government are subject to the conflict of interest statutes and regulations, including the Standards of Ethical Conduct. Additional information regarding the NIA IRP is available at the following website: www.irp.nia.nih.gov.