Senior Scientist, Protein Biomarker Identification and Assay Development


Johnson & Johnson


La Jolla, California


Apply here: Requisition No. 2306109282W.


The position of senior scientist, neuroscience biomarker research, primarily includes laboratory work within Janssen Neuroscience Biomarkers, which sometimes includes collaboration with commercial and academic laboratories.

  • The senior scientist will be responsible for identifying biomarkers relevant to the biology/pharmacology targeted by the clinical teams and the best fit for purpose assay technology.
  • The research will be focused on development of existing and new assays and assay strategies related to biomarker application and validation. This may include transfer of assays to commercial vendors. 
  • The role will include collaboration with discovery, translational medicine, and clinical research colleagues to implement biomarker measurements that will inform and improve decision-making for the Neuroscience drug portfolio.
  • The senior scientist will serve as an assay expert to neuroscience biomarkers disease area leaders and in support of clinical teams.
  • As part of assay development research, he or she will work with internal and external collaborators, partners, CROs, and key opinion leaders.
  • The senior scientist will have responsibility for recommending sample volume, acquisition, and handling requirements to operations and clinical teams, and work with the operations team to maintain an up to date tracker of available biomarker samples.
  • The senior scientist will assist with data analysis and interpretation and, with neuroscience biomarker leaders, communicate results to internal and external organizations.
  • The senior scientist will remain current on the evolving landscape of biomarker technologies and applications and relevant drug mechanisms of action.
  • The senior scientist will assist in collaborations with academic, industrial consortia, and commercial partners to optimize support of neuroscience biomarkers. 

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


  • Ph.D. (pharmacology, biochemistry, molecular/cell biology, immunology, biological engineering or related field) with at least five years postdoctoral experience focused on biochemical studies of protein/peptide expression and related methodologies is required.
  • Demonstrated ability for bringing robotic/automated solutions to assay development in research-oriented laboratories is strongly preferred.
  • Experience building new immunoassays using multiple assay platforms is strongly preferred.
  • Project management experience strongly preferred.
  • Demonstrated ability for bringing robotic/automated solutions to assay development in research-oriented laboratories is strongly preferred.
  • Experience collaborating in the deployment of new or specialized technology for novel assay development is strongly preferred.
  • Knowledge and experience in characterizing proteins and immunoreagents using kinetic tools (e.g. Biacore, ultracentrifugation, IP-MS/MS, plate-based kinetic assays, etc.) is strongly preferred.
  • Experience in sample preparation using CSF and blood (whole cell, whole blood, plasma/serum) and other biofluids is strongly preferred.
  • Established scientific achievement as demonstrated by a robust publication record is required. 
  • Excellent organizational skills to support preclinical and clinical study sample analysis is required. 
  • Excellent communication, data analysis and interpretation skills are required.
  • Proven ability to work in a team environment and to lead projects with minimal supervision is requried.
  • The position may require up to 10 percent travel.