Senior Research Fellow – Neural Circuits in Alzheimer's Disease


University College London


London, England, United Kingdom

Principal Investigator

Marc Aurel Busche



The Busche lab ( employs molecular, optical, electrophysiological, and behavioural methods to reveal the cellular and circuit determinants of the devastating learning and memory impairments observed in individuals with Alzheimer’s disease and related dementing illnesses.  This is an exciting time to be working in this area, as those methods allow us to monitor and manipulate activity and trace connections in defined circuits and cell types, and thus offer a completely new way to study dementia.

We are now looking for a highly motivated and proactive individual to lead an exciting project aimed at the deep phenotyping of the impairments of hippocampal cells and circuits in models of AD using in vivo electrophysiology, 2-photon microscopic imaging, light-sheet imaging, and transcriptomic analyses.

The successful candidate will be self-directed with excellent research skills, capable of working collaboratively in a team of researchers while maintaining independent thinking and initiative. This is an excellent opportunity to work independently on a high-impact, state-of-the-art project in a stimulating and social international research environment, undertaking world-class science under the guidance of a leader in Alzheimer’s pathophysiology.

The appointee is expected to determine the direction of the project and make significant conceptual contributions. Applicants who are motivated to develop careers as independent investigators are therefore especially encouraged to apply.


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