Posted 18 Aug 2019
University of Washington
Please contact Brian Kraemer at firstname.lastname@example.org to express interest in the position.
The laboratory of Brian Kraemer seeks a motivated individual who works well with others to join a mu,ltidisciplinary collaborative research team focused on the molecular genetics of aging-associated neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and related dementia disorders. The lab is investigating the molecular mechanisms of aging-induced protein aggregation and neurodegeneration using forward genetic approaches. Specifically, its researchers have identified many genetic suppressors of the neurodegenerative phenotypes caused by transgenic human tau and TDP-43 protein expression in C. elegans neurons. They have identified several intriguing candidate genes involved in RNA processing that are ripe for a new postdoctoral researcher to translationally characterize further using behavioral, genetic, and biochemical analyses. By completing these studies, the researchers aim to nominate novel therapeutic target genes for translation studies in rodent models of neurodegenerative disease. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. This research project is supported by an NIH funded R01 grant.
Compensation will be consistent with UW postdoctoral pay scale.
- A Ph.D. in a relevant field of biomedical science.
- Experience designing and executing well-controlled experiments.
- Strong writing skills.
- Strong verbal communication skills.
- Ability to work both independently and as a cooperative part of a team.
- U.S. citizenship or permanent resident status.
Desired experience/knowledge/skills include:
- Experience in genome editing using CRIPSR/Cas9 methods.
- Experience in molecular cloning and transgenesis methods.
- Experience with genetic analysis methods in model organisms.
- Experience assessing protein aggregation.
- Experience in advanced microscopy techniques.
- Knowledge of RNA binding protein function.
- Knowledge of the pathobiology of neurodegenerative disease.
- Knowledge of the biology of aging and disease.
- Knowledge of neurobiology.