Research Scientist I - Prion


Broad Institute Center for the Science of Therapeutics


Cambridge, Massachusetts


Broad Institute


Prions@Broad, a focused therapeutic program at the Broad Institute's Center for the Science of Therapeutics, seeks a highly motivated and independent scientist to join a multidisciplinary project team.

The successful applicant will apply multiple in vitro biophysical screening approaches in search of small molecules that bind and modulate the human prion protein (PrP).

Within the established goal of identifying PrP binders, the position includes latitude for an experienced and creative individual to drive the project in new directions and incorporate approaches beyond those listed above.

The goal of this project, over the next 10 years, is to identify and develop a small molecule that will prove an effective therapeutic for human prion diseases. PrP is a deeply genetically validated, if difficult, protein target. This position is ideal for a driven individual who is passionate about and focused on this goal, flexible in approaches within the larger goal, and comfortable with outcome-based, translational pragmatism.

For more information on this research initiative, see

To see the story behind this program view this video.

Principal duties and responsibilities:

  • Work as part of a team developing and executing large-scale, high-throughput chemical biology screens to identify one or more small-molecule binders of the human prion protein, PrP.
  • Perform follow-up in vitro and cell-based studies to validate and characterize PrP binders identified through small molecule screens.
  • Collaborate with chemists within the lab to spearhead structure-activity relationship studies to further characterize and optimize lead compounds.
  • Lead and execute research projects independently.
  • Attend weekly team meetings to present results and ensure that projects support current team goals.
  • Help train, supervise, and mentor junior staff as needed.

EOE / Minorities / Females / Protected Veterans / Disabilities.


  • A doctorate in areas such as chemical biology, chemistry, molecular biology, or allied fields. (Postdoctoral or further work experience is helpful.)
  • Experience with in vitro small-molecule screening techniques, including but not limited to all or some of the following: NMR, differential scanning fluorimetry, DNA-encoded library affinity enrichment, differential scanning calorimetry, isothermal calorimetry, and circular dichroism.
  • Experience strategically directing, organizing and interpreting in vitro small-molecule screens. A ruthlessly critical eye for artifacts is essential.
  • The ability to work independently and be flexible as priorities shift.
  • Excellent analytical, interpersonal, and oral and written communication skills.
  • Outstanding organization and time management skills.
  • Ability to spearhead and foster collaboration in a team environment.
  • Experience supervising junior scientists at the bench, and an enthusiasm for mentorship, are highly valued.
  • Candidates are encouraged to apply as early as possible. The center will review applications on a rolling basis with the goal of the earliest possible start date.