Project Scientist TMF


University of California, Irvine’s Institute for Memory Impairments and Neurological Disorders


Irvine, California


Please submit a letter of interest, curriculum vitae which should include a record of research experience and the names of three references before July 8, 2019, to:


This is an opportunity for a Project Scientist to join the UCI Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD) Disease Modeling Project (DMP). MODEL-AD is an NIA/NIH-funded multiproject, multi-institutional grant whose goal is to produce the next generation of mouse models for late-onset AD and develop new therapeutic targets. Under the direction of Grant MacGregor, professor and director of the UCI Transgenic Mouse Facility, the successful applicant will be responsible for (1) use of recombineering with human BAC genomic DNA clones to develop and verify vectors to be used to substitute mouse genes with human genes in mice and (2) performing protein extraction and western analysis to quantify specific proteins in wild-type and genetically modified mice. The project involves use of contemporary methods of genome engineering in mice, combined with assisted reproduction and germplasm and pre-implantation embryo cryopreservation.

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer committed to excellence through diversity. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.


Candidates with a doctoral degree in biology, molecular biology and biochemistry, bacterial genetics or related fields are encouraged to apply. Preference will be given to candidates with demonstrated knowledge and prior experience of bacterial recombineering using BACs; extensive knowledge of bacterial/plasmid genetics pertaining to recombineering; and experience in protein extraction, PAGE, and western blotting. Eligible candidates should also possess a strong work ethic, excellent time-management and record-keeping skills, the ability to multitask and work independently. In addition, candidates must be able to see projects through to completion, have strong record-keeping, and verbal and written communication skills.