Jobs

Project Scientist

Posted 17 Oct 2023

Employer

University of California, Irvine

Location

Irvine, California

Contact

Please submit a letter of interest, curriculum vitae which should include a record of research experience, and the names of three references before December 9, 2023, to: https://recruit.ap.uci.edu/apply/JPF08718.

Description

This position is within the UCI Model Organism Development and Evaluation for Late-onset Alzheimer’s disease (MODEL-AD) Disease Modeling Project (DMP). MODEL-AD is an NIA/NIH-funded multiproject, multi-institutional grant whose goal is to produce the next generation of mouse models that can be used to investigate mechanisms of late-onset AD (LOAD) and develop new therapeutics for this disease. The DMP works closely with the UCI Transgenic Mouse Facility (TMF) to accomplish the goals of the UCI MODEL-AD program. Under supervision of the DMP co-director and the TMF Manager, the successful applicant will oversee and assist with production of cohorts of mice for experimental analysis, will manage a large colony of genetically modified AD mice, and will interact closely with DMP members to facilitate analysis of newly developed genetically engineered models of late onset AD. The duties include:

• Participate in DMP and TMF meetings to review and establish priorities for production and analysis of new lines of genetically modified mice for the MODEL-AD group.
• Develop schemes for breeding and assisted reproduction to enable efficient production of multiple independent strains of genetically modified LOAD mice.
• Establish breeding and perform IVF and surgical transfer of embryos to pseudopregnant female mice to generate animals with appropriate combinations of genetic modifications.
• Schedule and cryopreserve sperm and pre-implantation embryos from strains of genetically modified mice.
• Schedule and track transfer of cohorts of mice to different MODEL-AD cores for analysis.
• Communicate and coordinate animal transfers to The Jackson Laboratory and other investigators via UCI ULAR.
• Develop PCR genotyping assays for newly generated strains of genetically modified mice.
• Manage CLIMB database to track genetically modified mouse development and use.
• Manage MODEL-AD mouse colony size within budgetary constraints.

The University of California, Irvine, is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

Requirements

• Bachelor's, master's, or Ph.D. with experience in mouse reproduction and genetics.
• Experience in breeding and genotyping genetically modified mice.
• Excellent eye-hand coordination.
• Isolation and manipulation of mouse pre-implantation embryos and sperm, and microsurgery experience strongly desired, although on-the-job training can be provided to qualified and motivated applicants.
• Experience in database handling (relational database, Excel, R, etc) strongly desired.
• Experience in qPCR and probe design strongly desired.
• Strong communication skills.
• Strong organizational skills.