Project Scientist




Irvine, California

Principal Investigator

Please submit a letter of interest, curriculum vitae which should include a record of research experience and the names of three references before 01/18/2023 to:


Document requirements

Reference requirements

Three letters of reference required

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The Thompson Lab has an open position for a highly independent project scientist with expertise in systems biology, human iPSC modeling, and mouse biology with a focus on data analysis and coordination of large biological datasets. Candidate must have experience with modeling Huntington’s disease using iPSCs and post-transcriptional analysis of large RNA and protein data sets. The incumbent will be responsible for supporting several projects that focus on multicellular iPSC modeling of neurodegeneration and in vivo discovery and validation studies by coordinating and helping with strategic planning of projects objectives, and helping generate hypotheses based on data from multiomic analyses of models. The incumbent will also be involved in training graduate students and postdoctoral fellows with experimental design and multiomic datasets and help with analysis and visualization of datasets for laboratory publications. The incumbent should also have expertise in analysis of single-cell and single-nuclei RNA-Seq datasets, analysis of splicing events, and eCLIP methods. Incumbent is required to have strong public speaking ability and will be required to regularly organize and present scientific data at international conferences and collaborative meetings.

The University of California, Irvine, is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.


The candidate must possess a doctoral degree in biomedical science or equivalent and have experience with modeling Huntington’s disease using iPSCs and post-transcriptional analysis of large RNA and protein datasets. The candidate must be knowledgeable in neurodegeneration and splicing mechanisms, have strong skills in data analysis and integration of RNA-Seq, ATAC-Seq, and ChIP-Seq data, and experience in project management. Also required is a strong publication record, advanced writing skills, experience with grant writing, including R01 grants, and a proven record of success in obtaining grant funding. Candidates must be able to work effectively with interdisciplinary teams and to manage scientific projects within a complex organization; therefore, excellent interpersonal, organizational, and oral and written communication skills are essential. This position will be appointed at the level that is commensurate with the education and experience of the individual candidate.

Basic qualifications (required at time of application): Doctoral degree in biomedical science or equivalent.