Principal Scientist Neuroimmunology Alzheimer's
Posted 05 Oct 2020
Johnson & Johnson
La Jolla, California
The Neuroimmunology Discovery team within Janssen Neuroscience Therapeutic Area is seeking a principal scientist with expertise in neuroimmunology. This individual will be an experienced drug hunter with deep subject-matter expertise in innate/adaptive immunology with proven experience in pursing scientific curiosity for neuroimmune interactions in CNS (patho) physiology. The individual will be part of a drug discovery team with a mission of bringing novel therapeutics, addressing neuroimmune dysregulation in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and mood disorders. He/She will be responsible for oversight of in vivo neuroinflammatory models, aiding in drug-discovery efforts during lead optimization. The candidate will also be responsible for and expected to contribute toward target identification for neuroinflammatory CNS disorders, and add value to the neuroimmune portfolio. Core job description includes generating experimental data to drive projects, shaping drug-discovery strategy in neuroimmunology/neuroinflammation, managing people and projects, and representing the neuroimmunology leadership team.
PhD in immunology, neuroscience, or interdisciplinary biology with several years of highly productive drug discovery experience in neuroimmunology and neuroinflammatory disorders of the CNS required.
Demonstrated ability to apply the immunology training in application of CNS disorders of neuroimmunology is a prerequisite for the position. In vivo skills in immunophenotyping is a requirement.
Proficient in systems neuroimmunology, with both in vivo and in vitro capabilities. Candidate must be comfortable working in the laboratory and should be proficient with flow cytometry and immune cell sorting from peripheral and brain tissues.
Experience in probing microglial activation (transcriptomics to proteomics) in models of neuroinflammation is highly preferred.
Prior laboratory experience in models of Alzheimer’s, Parkinson’s, MS, or mood disorders is preferred.
Sufficient knowledge in pharmacology (PK-PD) to support neuroimmunology drug-discovery projects.
Prior experience with imaging-related techniques like immunofluorescent labeling of cells and tissues, confocal microscopy and/or two-photon microscopy, is nice to have.
Ability to study microglia in a dish, and modeling microglial inflammation towards understanding fundamental neurodegenerative biology is also welcome.