Jobs

Postdoctoral/Technician Position in the Genomics Group

Employer

BarcelonaBeta Brain Research Center Foundation (BBRC)

Location

Barcelona, Spain

Contact

Please send curriculum vitae, cover letter describing research interests and relevant background and contact information for three reference to: rh@barcelobabeta.org.

More information: https://www.barcelonabeta.org/en/bbrc-research-center/job-offers.

Description

The BBRC has recently opened a Genomics lab, led by  Arcadi Navarro, and the Center for Genomic Regulation (CRG) and the Institute for Evolutionary Biology (IBE, UPF-CSIC). The group focuses on the genomic architecture of age-related disease—including neurodegenerative disease—and on the analysis of full genomes, epigenomes, and transcriptomes to ascertain the processes, variants, and molecular features that underlie human aging patterns. Amongst other projects, the group plans to undertake functional analysis on the effects of particular mutations in a number of experimental models, ranging from cell lines to brain organoids. These projects will carried out in collaboration with Sandra Acosta’s lab at the University of Barcelona (UB).

About the job

Amongst other things, the immediate aim of the project is analyzing the phenotype of AD brain organoids with different degrees of genetic risks. The main activities in this position comprise the reprogramming of fibroblasts into iPSC and the generation of brain organoids, mainly cortical and minibrain, and their phenotypic characterization using a wide range of technologies including advance microscopy, mesoscopy, and molecular techniques.

Additional responsibilities involve career-development activities, mainly contributing to publication and article-writing, managing the lab, and mentoring junior lab members in their projects.

We are hiring at any seniority level, so we encourage the application by all prospective Ph.D. students, technicians, and postdocs.

Main Responsabilities

  • iPSC reprogramming and maintenance and brain organoid generation.
  • Advanced microscopy and mesoscopy phenotyping.
  • Immunofluorescence, western blot, gene expression analysis.
  • Assists with the instructing and training of students, fellows, technicians, and laboratory assistants as required.
  • Participates in regular internal meetings as well as external collaborations.

Requirements

Must have
• Either an M.Sc. in neuroscience-developmental biology or biomedicine and/or a Ph.D. in neuroscience or developmental neurobiology.
• Experience in iPSC-derived neural differentiations.
• Experience in confocal microscopy.
• Excellent communication and writing skills in English.
• Ability to work collaboratively and with a high degree of autonomy.
• High motivation and organizational skills.
• You have excellent knowledge and follow Good Laboratory Practices (GLPs).

Desirable but not required/Nice to have

• Experience in bioinformatic analysis.
• Experience in human sample handling.
• Experience in laboratory management (lab safety, upkeep and trouble-shooting of lab equipment, and other organizational functions).
• Basic knowledge in statistics.