Jobs

Postdoctoral Scientist - Neurodegeneration

Employer

University of Kentucky Sanders-Brown Center on Aging

Location

Lexington, Kentucky

Principal Investigator

Linda Van Eldik

Contact

Apply online: https://ukjobs.uky.edu/postings/327064

Description

A postdoctoral scientist position is available immediately at the University of Kentucky. We seek a highly motivated, creative, and collaborative individual to work on mechanistic and translational research projects focused on the detrimental inflammatory and neurodegenerative responses that contribute to pathophysiology in a mouse model of comorbid vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease (AD). A component of this project will utilize a novel brain-penetrant small molecule as an anti-inflammatory strategy to combat inflammatory-related pathophysiology to determine optimal dosing and timing in the comorbid disease environment. Anticipated approaches to delineate comorbid pathophysiology response will include a multifaceted approach harnessing multiphoton vascular imaging in intact animals, flow cytometry, and cell sorting for transcriptional profiling, as well as cognitive phenotyping.

The position is in the Sanders-Brown Center on Aging, an established research center in aging and dementia where independent basic and clinical scientists work in a collaborative environment. The Center on Aging also includes the NIH-funded Alzheimer’s Disease Research Center that provides unique and outstanding resources to support innovative research (e.g., longitudinally followed and well-characterized clinical cohorts, neuroimaging, biomarkers, autopsy specimens).

The University of Kentucky is an equal opportunity employer and encourages applications from minorities and women.

Requirements

Ph.D. or M.D./Ph.D. in an area relevant to pharmacology or neuroscience. Must have excellent interpersonal, organizational, verbal and written communication skills, a solid publication record, and appropriate experience. Preference will be given to individuals with experience in one of the following areas: inducible conditional knockout mouse models, mouse neuropathology and behavior, primary glia/neuron cell culture, gene expression profiling, pharmacological modulation of glia signaling pathways.

Prior experience in AD, TBI, or related neurological disease research is also desirable.