Posted 18 May 2020
Center for Addiction and Mental Health
Toronto , Ontario, Canada
Qualified applicants should provide the following documents: Cover letter outlining research experience and interests; curriculum vitae; and the names and contact details for three references to Dr. Yu at firstname.lastname@example.org. Pre-inquiries also welcome.
Deadline: June 30, 2020, or until filled.
Note: Position start date is as soon as possible, but dependent on government pandemic response and (if applicable) immigration sponsorship decision. The Center for Addiction and Mental Health is seeking a talented postdoctoral scientist.
- A self-motivated and driven individual who is able to exhibit exceptional research productivity and take responsibility for independent management of a project.
- A detail-oriented researcher who still keeps a clear grasp of the big picture.
- A team player who proactively shares knowledge and expertise with lab members.
- Excellent written and oral communication skills are essential for career development.
The position is available for a motivated, industrious and ambitious scientist to use or establish biochemical, cellular and in vivo models to investigate the impact of proteostasis and extracellular vesicles in neurodegenerative diseases including Alzheimer’s disease, tauopathies, and Parkinson’s disease. Two positions are available depending on research expertise.
The laboratory employs a multidisciplinary translational approach involving biochemistry and neuroanatomy using numerous disease model systems, including neuronal and astroglial cultures (primary and iPSC-derived), rodent models of pathology, and human tissue/biofluids to elucidate the biological function and pathophysiological mechanisms of proteinopathies linked to neurodegenerative diseases. For this project, the lab is particularly interested in i) a scientist for the development and use of induced pluripotent stem cell (IPSC) models and the use of CRISPR/Cas9 to characterize cellular phenotypes associated with patient-derived mutations; and ii) a scientist with experience in animal models, neurocircuitry and cognitive measures. Both projects intersect in the translation of these findings to human events, in an effort to target therapies and biomarkers for early detection of disease.
The Yu lab works on identifying the mechanism for proteostasis in the brain and how dysfunction can be reversed. Another project will also investigate if proteostasis can be used as an early biomarker for neurodegeneration, based on preclinical models as well as from patient cohorts. The candidate postdoctoral fellow will have an opportunity to participate in the development of this exciting translational research.
- A recent Ph.D. or M.D. with demonstrated experience in any of the following fields: cell biology, in vivo models, biochemistry, and/or neuroscience. At least one first author publication in these fields is desirable.
- A preferred candidate will have experience in any of the following research areas: IPSC-derived neuronal culture models; confocal and/or stereological microscopy; viral vector technology; development and characterization of genetic animal models; single-cell sequencing; molecular/cellular neurobiology.