Postdoctoral Researcher/ Staff Scientist




Flanders, Belgium

Principal Investigator

Bart De Strooper



The Laboratory for the Research of Neurodegenerative Diseases headed by Prof. Bart De Strooper is a vibrant environment where key issues related to Alzheimer’s disease are tackled. It is currently looking for a highly skilled and motivated postdoc to join our multidisciplinary project on the cellular response to Alzheimer’s pathology. The lab has used spatial transcriptomics to investigate why some people remain protected against Alzheimer’s disease despite the presence of amyloid plaques. Understanding resilience to Alzheimer’s disease will help researchers identify new drug targets. They are looking for an expert postdoc to validate these targets using cutting edge Perturb-Seq and other approaches.

The successful candidate will closely collaborate on discovery biology, interpretation, and identification of novel drug targets, together with the wider team of biologists and bioinformaticians. The successful candidate will be responsible for the target mining and validation. This project is funded by an industrial project in collaboration with a biotech start-up.


Ph.D. in biomedicine, genetics, or equivalent.

Strong background and hands-on experience with genome editing and CRISPR/CAS9 technologies.

Experience with cell culture and animal models.

Strong interest in drug discovery and development.

Strong interest to work in the field of Alzheimer’s disease.

Critical mindset, fast learner, and team player.

Ability to collaboratively lead a multidisciplinary project with international and national partners in academia, industry and the clinics.

Effective project management and communication skills.

Good mastery of English language appreciated.

Experience with Perturb-Seq or Crop-Seq or similar technologies.

Knowledge of the genetics of Alzheimer’s disease.

Experience with image analysis and/or statistics.

Experience with computational biology and data analysis.

Knowledge of spatial or single-cell omics applications.