Jobs

Postdoctoral Researcher in Cell biology and Alzheimer’s disease (scholarship)

Employer

Karolinska Institutet, Department of NVS, Division of Clinical Geriatric

Location

Campus Syd - Flemingsberg, Sweden

Principal Investigator

Maria Eriksdotter

Contact

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

Apply by 15th of Jan 2023 at the latest.

The appliction is to be submitted on the Varbi recruitment system, https://ki.varbi.com/en/what:job/jobID:570587/.

Description

The Institute is looking for an enthusiastic and highly motivated scientist who is interested in working in a multidisciplinary team at the forefront of translational Alzheimer’s disease. Maria Eriksdotter's research group aims to investigate how mitochondrial function is affected by intracellular cholinergic signaling in AD and age-related disorders. The study is aimed at providing new insights to combat the selective degeneration of cholinergic neurons and mitochondrial function, and thereby to a new disease-modifying/curative therapy. In relation to this, the research group wants to investigate the crosstalk between the cellular ACh machinery, the mitochondrial bioenergetics and cellular senescence and apoptosis.

Duties: The scientist will conduct in vitro studies using cholinergic cell lines, that systematically will be investigated for changes in cellular ACh level and its machinery as well as mitochondrial (mt)-ACh receptors, with regard to gene and protein expression and cellular localization first in various cellular models, and then in astroglia and primary neuronal culture under basal condition as well as following exposure to relevant stress stimuli seen in age-relate disorders, such as AD.

The scientist is expected to take an active role in designing the studies and applying a diverse battery of biochemical and pharmacological methods for cell cultures and animal models. He or she will also be involved in supervising, training, and planning high quality smaller master-degree study projects for national and international students.

The salary is tax-free and it is set for 12 months at a time, paid out on a six-months basis. In exceptional cases, shorter periods may be acceptable.

Requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent. To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate, preferably within biological or biomedical field. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

The department seeks a highly motivated postdoctoral researcher. Preferably, he or she will have done a Ph.D. study in mitochondrial related diseases, or neurodegeneration disorders. Applicants should have very good pharmacological knowledge and have good experience with performing such studies in cell culture systems—in other words, hands-on experience with two- or three-dimensional cell culture studies and skill performing immunohistochemistry and cytochemistry. Applicants should also have very good understanding of data processing and statistical analyses. Experience with studying mitochondrial function, morphology and mitochondria-driven apoptosis are highly desirable merits. Tasks include writing manuscripts and presentation of scientific data, so excellent oral and writing skills in English are required, as is good organization and planning, ability to work independently and keeping the deadlines. Applicants should also be a highly motivated team-players with positive proactive attitudes towards working with national and international collaborators.

This postdoctoral scholarship is for one year initially with the high possibility of extension for a further year, considering all the criteria are fulfilled.