Posted 02 Feb 2018
University of Eastern Finland
The Faculty of Health Sciences at the University of Eastern Finland is inviting applications for a postdoctoral researcher position, A.I. Virtanen Institute for Molecular Sciences, Kuopio Campus. The position relates to a project that is sponsored by a pharmaceutical company. The chosen candidate will be based in the group of Associate Professor Tarja Malm and the project will be carried out in tight collaboration with the company.
The aim of the project is to characterize the impact of Aβ and/or tau pathology on synaptic function and structure using electrophysiology and two-photon imaging of biopsied human brain tissue obtained from idiopathic normal pressure hydrocephalus (iNPH) patients, some of whom have concomitant Alzheimer’s pathology. Early aims will be to set up electrophysiology protocols and assays to analyze intrinsic membrane properties and understand different neuronal response properties as a function of Alzheimer’s pathology. These experiments will be complemented with functional and structural imaging of synapses using genetically-encoded fluorescent reporters using two-photon microscopy.
The researcher will join a very active and well-equipped group of neuroscientists studying various aspects of neuronal function, neuroinflammation in the context of different neurological diseases, and will have a direct interaction with the experts in the neuroscience behind Alzheimer’s disease and therapeutics based at the company.
The position is filled for one year starting from March 15, 2018, or as agreed. The position is filled for a fixed term due to the duration of the project.
The salary of the position is determined in accordance with the salary system of Finnish universities and is based on level 5 of the job requirement level chart for teaching and research staff (€2,865.30/month). In addition to the job requirement component, the salary includes a personal performance component, which may be a maximum of 46.3 percent of the job requirement component.
For more information, see http://www.uef.fi/fi/uef/avoimet-tyopaikat.
The candidate should have a Ph.D. in neuroscience or a related discipline with experience analyzing functional properties of neuronal circuits. Candidates with a Ph.D. in physics or engineering and with sufficient background in neuroscience are also encouraged to apply. Strong and proven experience in slice electrophysiology is desired. In addition, experience in immunohistochemistry, two-photon imaging, image and data analysis is advantageous. Enthusiasm and commitment will need to be coupled to attention to detail and strong analytical skills. Good knowledge of written and spoken English is essential. An ideal candidate must have a high degree of independent thought and initiative. The applicant needs to have recommendation from two previous and recent supervisors/PIs.