Jobs

Postdoctoral Research Scholar

Employer

UCSF

Location

San Francisco, California

Principal Investigator

Fanny Elahi

Contact

Please send CV, a statement of career goals (limited to one page), and contact information for three references to lab PI Fanny Elahi, M.D. Ph.D.

Description

The Elahi lab is looking for a highly motivated, creative, and enthusiastic scientist with a record of productivity and prior experience with molecular biology techniques to join the lab as a postdoctoral research scholar. The focus of the lab is on understanding contributions from endotheliopathies and vascular dysfunction to brain aging and neurodegeneration. The lab is developing novel multimodal analytical approaches combining deep clinical phenotyping with cutting-edge imaging methods (brain and retina) and molecular and cellular phenotyping to better characterize molecular pathways through which vascular disease contributes to brain degeneration. The project will involve deep characterization of human derived extracellular vesicles and determination of functional effects with in vitro systems, including human primary cell cultures. A background in exosomal biology, flow cytometry, micro-RNA sequencing, protein mass spectrometry, and in vitro functional assays will be assets. The lab is involved with national consortia studying vascular contributions to cognitive impairment and dementia in large human cohorts. Therefore, in addition to leading projects, the scholar will have the opportunity to participate in several highly impactful collaborative projects and utilize cutting edge technology to look at fascinating patient populations.

Responsibilities will include designing and conducting experiments, analyzing data, preparing and presenting research findings at meetings, leading or contributing to the writing of scientific manuscripts, applying for fellowships and other research funding.

The Elahi Lab is passionate about advancing knowledge of brain aging and neurodegenerative disease toward discovery of novel therapeutic targets. We hope to find someone who shares our commitment to improving brain health in aging and disease states.

The department also has a postdoctoral fellow training program focused on mentorship, networking, and recognition.

Duration: Two years with advancement to the second year contingent upon satisfactory progress during the first year. The appointment may be extended beyond two years depending on funding and satisfactory performance.

Equal Employment Opportunity

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Requirements

Required Qualifications

  • Ph.D., M.D., or M.D./Ph.D. degree in a related science, and prior experience utilizing the techniques or methods required by the position; or an equivalent combination of education and experience
  • Data analytic skills and working knowledge of biostatistics including the use of statistical packages of choice.
  • Ability to multitask and prioritize.
  • Excellent written/verbal English communication skills.
  • Strong organizational skills, and the ability to take initiatives and work independently.
  • Meticulous record-keeping abilities.

Note: Classification and salary will depend on the qualifications of the applicant.

Preferred Qualifications

  • Prior experience working with extracellular vesicles, and/or induced pluripotent stem cells (iPSC), and/or molecular omics, such as RNA-Seq or proteomics data.
  • Conceptual understanding and knowledge of any of the following: neurobiology, aging vascular disease biology, immunology (or related disciplines).
  • Advanced biostatistics and data science skills.
  • Experience working with primary brain cell cultures, e.g., brain astrocytes and neurons, in addition to endothelial cells.