Jobs

Postdoctoral Research Fellow

Employer

Washington University School of Medicine

Location

St. Louis, Missouri

Principal Investigator

Gilbert Gallardo

Contact

gallardog@neuro.wustl.edu

Description

A postdoctoral research fellow position is available at Washington University School of Medicine in St. Louis. The laboratory of Gilbert Gallardo, in the Department of Neurology, is recruiting postdoctoral research fellows to study the cellular mechanisms of neurodegeneration of Alzheimer’s disease. These positions are NIH-R01 funded. The lab is particularly interested in studying astrocytes and neuroinflammation as several studies, including its own, are demonstrating astrocytes are a critical component of neurological disorders.

The lab's studies aim at 1) determining the extent to which mitigating reactive astrocytes are neuroprotective, 2) identifying an astrocytic mechanism that contributes to AD, and 3) identifying toxic neuroinflammatory molecules for the potential of therapeutic intervention of AD. It also develops immunotherapeutic approaches targeting the pathological protein tau in AD and related tauopathies. 

The emergence of tau as a target for immunotherapy raises several fundamental questions including 1) can we engineer immunotherapeutics optimized for tau depletion, 2) is a combination of immunotherapy with gene therapy a feasible approach for long-term treatment, and 3) does the progression of tau pathology in these diseases involve spreading pathological tau from cell to cell via the extracellular space in the brain? To answer these questions the lab has engineered a series of single-chain fragment variables (scFVs) directed against human tau. These anti-tau scFVs serve as molecular tools for engineering immunotherapeutics optimized for tau depletion.

Washington University School of Medicine in St. Louis is an equal opportunity, affirmative action educator, and employer.

Requirements

Candidates must hold a Ph.D. or M.D. and should have some background in molecular/cellular biology, preferably with experience in handling animal models.