Postdoctoral Research Fellow
Posted 23 Aug 2021
The University of Edinburgh
Edinburgh, Scotland, U.K.
The Montagne lab combines molecular approaches (e.g., scRNA-Seq) with rodent noninvasive imaging, particularly magnetic resonance imaging (MRI) and two-photon microscopy, to study the causes and effects of blood-brain barrier (BBB) dysfunction in the context of neurodegenerative disease. BBB dysfunction is a major cause of inflammatory and bioenergetic deregulation in the brain, but the interplay between pericytes and endothelial cells that causes this collapse is not fully delineated. The Montagne lab is now focusing on probing BBB function and pericyte-endothelial crosstalk, especially the consequences of pericyte dysfunction on endothelial cells and the BBB, plus reciprocal signaling by activated endothelial cells.
The post-holder will contribute to the development of this program by performing high-quality, original research, and producing material for publication and dissemination.
- Design, perform, and analyse experiments. Master new techniques when necessary = 70 percent.
- Maintain accurate and up-to-date records of experimental and analytical work.
- Regularly summarise progress in high-quality figures. Regular reporting of progress to the PI/other members of the research team is expected.
- Presentation of research findings at national and international level = 10 percent.
- Keep up to date with related published work. Promote scientific discussion in the lab. Actively participate in the development of the lines of research and the intellectual and technical growth of the lab = 8 percent.
- Take a lead role in writing up data for publication. Contribute to the dissemination and publication of own/research team’s research findings = 5 percent.
- To provide guidance and supervision for student projects and/or instruction of students in the use of equipment/demonstration of techniques = 4 percent.
- Help with the preparation of research proposals and applications to external funding bodies = 3 percent.
More information and application here: https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/1758/?utm_medium=jobshare.
- A Ph.D. (or near finish) in biomedical sciences, neuroscience, bioinformatics, or similar.
- Strong molecular biology skills.
- Ability to communicate complex information clearly, orally and in writing.
- Capacity and willingness to work and collaborate with other people.
- Some experience (or at least knowledge) with the current transcriptomics techniques.
- Strong knowledge in vascular biology and dementia in general.
- Previous experience with bulk and/or single cell RNA-sequencing data and analyses is highly desirable.
- Experience with in situ hybridization techniques.
- Advanced understanding of genetic engineering.
- Publications in peer-review journals including first author papers.
- Some experience with transgenic reporter and CreER mouse lines.