Jobs

Postdoctoral Research Fellow

Employer

Brigham and Women's Hospital

Location

Boston, Massachusetts

Principal Investigator

Cynthia Lemere

Contact

For more information about the Lemere Lab, please visit https://www.brighamandwomens.org/research/labs-and-projects/lemere/overview.

For consideration for this position, please send a cover letter explaining your background and motivation, detailing how you feel your skills can enrich the group’s activities and whether you require sponsorship now or in the future to work in the United States, contact information for three (3) references, and a full CV including contact details as a combined PDF to:

Cynthia Lemere, Ph.D.
Associate Professor of Neurology, Harvard Medical School
60 Fenwood Road
Boston, MA 02115
Email: clemere@bwh.harvard.edu

Description

A postdoctoral fellow position is available immediately in the Lemere laboratory at Brigham and Women’s Hospital to utilize a novel antibody to prevent amyloidosis, inflammation, and synaptic dysfunction in Alzheimer’s disease. This position is funded by an NIH RF1/R01 research grant titled “AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Aβ Antibody to Avoid Vascular Side Effects” under the direction of Dr. Lemere. The department will appoint the research fellow to the BWH Medical Staff and will propose that him or her be appointed as a research fellow at the Harvard Medical School (HMS); however, final approval of this appointment rests with HMS.

The Lemere Lab has made seminal discoveries regarding active and passive anti-amyloid immunization in amyloid mouse models over the past 20 years. These findings led to the establishment of an international collaborative effort between Dr. Lemere’s lab and Vivoryon Therapeutics (formerly known as Probiodrug AG) in Germany. The NIH-funded project involves in vivo immunization studies in mice including MRI brain analysis, microPET imaging, behavioral testing, and microglia single cell genomics, as well as in vitro examination of the neuroprotective effects of the antibody. The laboratory is funded by multiple NIH and NASA grants to support research studies related to testing of therapeutic treatments, understanding the role of complement in neurodegenerative diseases, and estimating the CNS and cardiovascular risks of deep space radiation. The ultimate goal of the laboratory is to discover novel therapies that are relevant to Alzheimer’s disease, neurodegeneration and radiation-induced injury.

Brigham and Women’s Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, creed, sex, sexual orientation, gender identity, national origin, ancestry, age, veteran status, disability unrelated to job requirements, genetic information, military service, or other protected status.

Requirements

The lab is looking for a candidate with a strong background in molecular biology techniques, mouse studies, tissue culture, confocal microscopy, and assays to quantify gene/protein expression. Experience with mouse behavior is desirable but not necessary. Prioritized candidates should demonstrate excellent scientific productivity, evidenced by high-quality publications, and be highly motivated to conduct independent research.

Additionally, candidates should display good communication and interpersonal skills. M.D., Ph.D., or equivalent is required.