Jobs

Postdoctoral Research Fellow

Employer

Brigham and Women's Hospital; Harvard Medical School

Location

Boston, Massachusetts

Principal Investigator

Cynthia Lemere

Description

A postdoc position is open in the laboratory of Cynthia Lemere in the Ann Romney Center for Neurologic Diseases in the Department of Neurology at Brigham and Women's Hospital and Harvard Medical School to study the role of complement in Alzheimer's disease. In particular, the research focuses on determining whether suppression of complement signaling early in Alzheimer’s pathology confers neuroprotection, the cell types involved, and sex differences.

The lab's previous work demonstrated that constitutive global deletion of complement C3, a central molecule in the complement cascade, protected against age- and amyloid-related cognitive decline and hippocampal synapse loss in aged wild-type and amyloid transgenic mice. The new project uses a novel inducible conditional knockout mouse model to suppress complement C3 at the onset of amyloid or tau pathogenesis. In addition, new models will be generated to induce suppression of C3 expression specifically in microglia or astrocytes. Readouts include behavioral testing and electrophysiology, as well as molecular, pathological and biochemical analyses. Candidates must have extensive experience working with mice.

This postdoc position is available immediately and fully funded for a minimum of three years. Compensation will follow NIH postdoctoral stipend levels and includes benefits. Applicants should submit a cover letter detailing their research experience and interests, a CV, potential start date, and full contact information for three references.

Requirements

  • A Ph.D. in neuroscience, neuroimmunology, or a related field.
  • Excellent track record of publications, especially in the Alzheimer’s field and/or complement biology.
  • Extensive experience with mouse studies, including behavior.
  • General experience in molecular biology, pathology and biochemistry.
  • Electrophysiology experience preferred.
  • Self-motivated and driven individual who is able to work both independently and in a team-oriented environment, and take responsibility for the overall management of the project.
  • Superb oral and written communication skills.
  • Minimum three-year commitment.