Postdoctoral position to study the impact of cellular senescence in AD
Posted 24 Aug 2020
This is a joint position between the Kapahi and Campisi Laboratories, which are collaborating to study the role of advanced glycation endproducts (AGEs) in cellular senescence and its impact on Alzheimer's disease. The labs use an interdisciplinary approach, combining genetic, pharmacological, biochemical, and genomic approaches in invertebrate model systems C. elegans, mice, and human samples.
The broader significance of this research is to help uncover the role of diet and AGEs in the etiology of age-related human diseases like diabetes and Alzheimer's disease.
The current position involves studying the role of glucose and Advanced Glycation Endproducts (AGEs) in diabetes and neurodegeneration using mice, and IPS derived cells. The labs will examine the mechanisms involved in synthesis and detoxification of AGEs and how they cause cellular damage. Previous background in cellular senescence and mouse genetics will be an advantage but not necessary. The candidate will receive training in specific area(s) of research to progress towards an independent career.