Jobs

Postdoctoral Position in Neuroinflammation of Alzheimer’s Disease

Employer

Washington University School of Medicine

Location

St. Louis, Missouri

Principal Investigator

Gilbert Gallardo

Contact

Qualified applicants are invited to submit a letter of application and their curriculum vitae, including three references' names and contact details, to g.gallardo@wustl.edu

Description

The laboratory of Gilbert Gallardo at Washington University School of Medicine in St. Louis is recruiting postdoctoral fellows to study neuroinflammation in Alzheimer's disease (AD) and develop novel immunotherapies. These opportunities are funded by the NIH and foundation grants. The lab is particularly interested in studying astrocytes as several studies, including its own researchers', are demonstrating that reactive astrocytes are a critical component of neurodegeneration. The studies aim at determining the extent to which suppressing astrogliosis is neuroprotective and investigating the cellular mechanism that regulates astrocytic reactivity.

The lab also aims to develop immunotherapeutic approaches targeting the pathological protein tau and neutralizing neuroinflammation in AD and related tauopathies. The studies have provided compelling evidence that pathological tau is an immunotherapeutic target. The emergence of tau as an immunotherapeutic target raises several fundamental questions: Can scientists engineer immunotherapies optimized for tau depletion, and is a combination of immunotherapy with gene therapy a feasible approach for long-term treatment? In addition, the lab's studies have highlighted that reactive astrocytes contribute to neurodegeneration, suggesting that suppressing their reactivity may be beneficial in reducing neuroinflammation in AD. The lab generates single-chain fragment variables (scFVs) that serve as molecular tools for engineering immunotherapeutics optimized for tau depletion or for neutralizing inflammation to address these aims.

Washington University is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

 

Requirements

Candidates must hold or be about to complete a Ph.D. or M.D. and should have a strong background in molecular/cellular biology. A track record of productivity with peer-reviewed publications, excellent organizational skills, fluent English, and less than two years of postdoctoral experience are required.