Jobs

Postdoctoral Position in Experimental Neuropathology of Diseases Caused by Protein Misfolding

Employer

Case Western Reserve University School of Medicine

Location

Cleveland, Ohio

Principal Investigator

Jiri Safar

Contact

Qualified applicants should submit a cover letter, current CV, and names and contact information for three references to: Jiri.Safar@case.edu.

Description

The laboratory of Jiri Safar has a postdoctoral position available under the NIH R01 five-year grant in collaboration with the Department of Physiology and Biophysics at Case Western. The laboratory utilizes cutting-edge biophysical and genetic tools, including transgenic mice, to study the mechanism of formation of prions and prion-like amyloids, their evolution and selection in the pathogenesis of Alzheimer’s and prion diseases. The Safar team has recently synthesized the first artificial human prion and ongoing projects are focusing on defining the mechanisms of prion formation and replication in different human neurodegenerative diseases.

Requirements

The project would be ideally suited to a postdoctoral fellow with Ph.D. or M.D., and experience in mass spectroscopy-based proteomics of protein misfolding diseases, and biochemistry of prions and prion-like proteins.