Postdoctoral Fellowship in Neuropathology of Alzheimer’s Disease




Jefferson, Arkansas

Principal Investigator

Elvis Cuevas



A postdoctoral fellowship opportunity is currently available in the Division of Neurotoxicology, National Center for Toxicological Research (NCTR) of the U.S. Food and Drug Administration (FDA) Jefferson Laboratories Campus.

Research efforts will include participation in multidisciplinary efforts in a nationally recognized training program in support of the FDA’s mission and be trained in evaluating sex differences in behavioral changes, vascular dysfunction (specifically Aβ transporters), neuronal pathology, glial activation, neuroinflammation, and biomarker identification in brains of the 3xTg mice model of Alzheimer’s disease (AD) and human AD postmortem tissues. Under the guidance of a mentor, the selected participant will learn to use various assays/techniques available in the NCTR's Division of Neurotoxicology, in data analysis from these experiments, in assistance with neuropathological/neurochemical assays. The participant will train with FDA investigators at NCTR and with investigators in other FDA centers. During the project, the participant will be actively encouraged to present the research at internal and external meetings and publish the findings in peer-reviewed journals.

The desired start date is March 15, 2020.

This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The appointment is up to three years and will be full-time. The participant will receive a monthly stipend commensurate with educational level and experience. Maintenance of proof of health insurance is required for participation in this program. Participants do not become employees of FDA, DOE, or the program administrator, and there are no employment-related benefits.


Within the last five years, applicants must have received a Ph.D., M.D., or equivalent in neuroscience, neurobiology, or toxicology. Priority will be given to those with a strong background in blood-brain barrier (BBB) biology. Desired qualifications include: brain capillary isolation, transport studies, and proficiency in confocal microscopy.