Postdoctoral Fellows in Microglia Biology and Neuroimmunology of Alzheimer’s Disease
Posted 03 Oct 2018
Icahn School of Medicine at Mount Sinai
New York, New York
Alison Goate’s laboratory in the Departments of Neuroscience and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (MSSM) in New York City is currently looking for highly skilled and motivated molecular and cell biologists to drive efforts to translate the human genetics of Alzheimer’s disease into effective preventative and therapeutic interventions. Core areas of focus will be translating genetics and human biology observations into both in vitro (induced pluripotent stem cell models) and in vivo systems (mouse models) to understand innate immune modifiers of AD pathogenesis. In particular, the lab concentrates on identifying human genetic variants associated with AD and dissecting the molecular, cellular, and tissue-level mechanisms by which these variants and the associated genes (e.g., APOE, TREM2, SPI1/PU.1, MEF2C, MS4A) modulate disease risk, with a major focus on the role of microglial cell function (e.g., phagocytic clearance of cholesterol-rich cellular debris) in the maintenance of brain tissue homeostasis during aging and in disease conditions. The candidate will join a multidisciplinary and highly collaborative research team that includes geneticists, computational biologists, immunologists, neuroscientists, and physician-scientists at the Ronald M. Loeb Center for Alzheimer’s Disease, as well as at other leading U.S. and European academic institutions and biopharmaceutical companies.
- Ph.D. in biology, neuroscience, immunology, or related field with deep expertise in molecular and cellular biology techniques.
- Strong research experience in microglia/macrophage biology (preferred).
- Strong research experience in mouse microglia/macrophage biology in vivo (preferred).
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- Strong research experience in human iPSC technology and targeted genome editing in vitro (preferred).
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Strong research experience in high-throughput technologies (e.g., NGS and
CyTOF) for bulk and single-cell transcriptomics, epigenomics, lipidomics and/or proteomics (preferred)
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- Strong research experience in functional genomics (e.g., siRNA, shRNA, CRISPR/Cas9, and chemogenomic) screens (preferred).
- Statistical and quantitative analysis skills.
- Basic bioinformatics skills (preferred).
- Self-motivated and highly dedicated experimentalist.
- Effective organizational and prioritization skills.
- Effective oral, written, and interpersonal communication skills.
- Ability to work both independently as well as collaboratively in a multidisciplinary environment.